2009-06-01 Air France flight 447 crashed with over 200 passengers on board in the Central Atlantic.
At this early point it seems the failure was initiated by severe turbulence. Wings have been known to snap off because of very strong up- and downdrafts. In this case it might not have been so severe, but a failure cascade might have started. Anyway, breakup was high in the air as the debris is scattered so widely.